| 1. | Aba is generated to response to osmotic stress in plant cells . h2o2 is recognized as the second messenger in aba signaling cascade
而各浓度级别的、无活性的sb202474分别和aba 、执o :共同处理，不影响气孔关闭。 |
| 2. | The hau3r gene was over - expressed when e . coli bl21 ( de3 ) ( phz2055 ) was induced with iptg , but the products existed in the form of inclusion bodies
在大肠杆菌bl21 ( de3 )中hau3 ~ r基因获得超量表达，但以无活性的包含体形式存在。 |
| 3. | The kid chymosin was secreted as being the form of non - activated prochymosin , and its activation depended on ph value , salt concentration and temperature . the lower the ph value was , the higher activated speed become
羔羊凝乳酶以无活性的酶原形式分泌， ph ，食盐和温度对其激活有重要的影响小h越低，激活速度越快，在phz |
| 4. | Which may provide the molecular basis for the inberine regulation of ll p - hsdl expression by glucocorticoids . secondiy , the regulation of l l 9 - hsdl expression and redutase activity by glucocorticoids was investigated in the primny cultured human chorionic trophoblast
整个妊娠过程中胎盘11 - hsd活性以氧化酶为主，使母体gc在进入胎儿循环前大部分被转化为无活性的17 -羟- 11 -脱氢皮质酮，保证胎儿正常发育所需的激素浓度。 |
| 5. | The rat 20a - hydroxysteroid dehydrogenase ( 20ahsd ) belongs to a family member of aldo - ketoreductases used nadph as a cofactor and principally converts progesterone to 20a - hydroxyprogesterone as a lower or non - active hormone . thus 20ohsd acts as a molecular switch and makes the potent progesterone hormone into an inactive potent metabolite
大鼠20 -羟类固醇脱氢酶( 20 - hydroxysteroiddehydrogenase ， 20 hsd )属于醛酮氧化还原酶系成员，在大鼠卵巢中以nadph为辅酶将孕酮转变为低或无活性的20 -羟孕酮。 |
| 6. | In the study , three drugs were gien to the olunteers : ssri ( serotonin specific reuptake inhibitor ) to raise serotonin leels ; nari ( noradrenaline reuptake inhibitor ) to raise noradrenaline leels ( another neurotransmitter important in depression , and also found in taste buds ) ; and an inactie placebo
在该项研究中，志愿者服用的三种药物是：提高5 -羟色胺水平的ssri （选择性5 -羟色胺再摄取抑制剂） ，提高去甲肾上腺素（另外一种对抑郁症有重要作用的神经递质，也存在于味蕾中）水平的nari （去甲肾上腺素再摄取抑制剂） ，以及无活性的安慰剂。 |
| 7. | The co - expression of l l6 - hsd1 and gr in the saxne chorionic trophoblast suggests possible intrcrine achons ofglucoconicoid generated by l l6 - hsdl within the cells . 2 . ewe radiomctric conversion assay showed that trctrient of the cells with the synthetic glucocorticoid - - dexarnethasone ( l0 - ' m ) for 24h increased the conversion of conisone to cortisol , and thes increase was blocked by the gr antagonist ru486
双标免疫组织化学染色结果显示11p hsdi和gr共存于同一个滋养层细胞，提示在体内无活性的gc代谢产物?一17羟d脱氢皮质酮经11p hsdi还原活化后可以直接与同一个细胞内的gr结合，即以内在分泌（ intracrine ）形式发挥作用 |
| 8. | The 11 - hsd1 expression in the fetal brain also gradually increases with gestational age at late gestation and continues to increase in the hippocampus after birth until the 15th postnatal day , which shows a pattern very similar to th secretion . furthermore , previous data show injection of thyroxine ( t4 ) to normal newborn rats up - regulates gr expression in the hippocampus . these data suggest that the role of th in neural development may be partially ( if not all ) accomplished through regulating gc ' s activity
在海马结构， 11 - hsd1与gr共存于同一海马神经元内，主要呈现还原酶的特性，能使无活性的11 -脱氢皮质酮( a )可的松( e )转化为有活性的皮质酮( b )皮质醇( f ) ，从而提高组织局部的糖皮质激素浓度，这样， 11 - hsd1的存在就为亲和力较低的gr发挥作用提供了前提条件。 |
| 9. | Renin - angiotensin system ( ras ) plays an important role in the regulation of peripheric blood pressure , where angiotensin converting enzyme ( ace ) is considered to be the core of the system . ace plays a key role in increasing the blood pressure by catalyzing the formation of the potent vasopressor angiotensin ii ( ang ii ) from angiotensin i ( ang i )
在该系统中， ace酶是血压调节过程中一个关键的酶，它可以将无活性的血管紧张素( ang )水解生成具有血管收缩作用的血管紧张素( ang ) ，从而导致血管收缩，机体的血压升高。 |
| 10. | L l6 - hsd2 is localized to the sppytiotrophoblast of the placenty providing a fimctional barrier protecting the fetus from matemal glucocorticoids . a sequence resembling glucocorticoid response element ( gre ) has been identified in the promoter region of the human l l0 - hsdl gene . glucocorticoids have been shown to induce the expression of 11p - hsdl in the hippomus in vitro " whereas controversial results were obtained in the hepatocyte
体内至少存在两型11 - hsd ，在细胞完整的状态下， 11 - hsd1主要为还原酶，它活化gc的代谢产物17 -羟- 11 -脱氢皮质酮(啮齿类为脱氢皮质酮)为有活性的皮质醇(啮齿类为皮质酮) ，而11 - hsd2为氧化酶，它催化皮质醇为无活性的17 -羟- 11 -脱氢皮质酮，因此11 - hsd1加强gc的作用，而11 - hsd2减弱gc的作用。 |
