Found the phenomenon observed in the nematode caenorhabditis elegans for the first time in 1998 , consequently similar processes have been described for drosophila melanogaster , trypanosome , mammals including humans . the mechanism is that sirnas is the mediator , which can induce the risc to the target mrna and degrade it . recently there was great progress in the specific gene therapy and anti - virus , and rnai has been a focus of rna molecular therapy 自1998年fire等在研究线虫时首次发现以来，相继在果蝇、涡虫、锥虫、小鼠及哺乳动物细胞中发现rnai现象。一般认为： rnai第四军医大学硕士学位论文效应作用机制是sirnaskmallinterferinguaduplex ）作为中介分于，引导risc （ rnaiinducingsuppresscomplex ）至靶基因m洲a处，随后核酸内切酶将之降解。
