Complications of chemonucleolysis include diskitis and sensitivity reactions ， including an 0 . 5 % incidence of anaphylaxis 化学核溶解法的并发症有椎间盘炎及过敏反应，包括0 . 5 %的过敏休克的发生率。
2.
Many nuclei have become pyknotic ( shrunken and dark ) and have then undergone karorrhexis ( fragmentation ) and karyolysis ( dissolution ) 细胞核固缩（缩小和深染） ，接着核碎裂（形成碎片）和核溶解（溶解消失） 。
3.
Chemonucleolysis is contraindicated in patients who are allergic to papaya or who have previously been injected with chymopapain 对番木瓜过敏的病人，或以前曾经注射过木瓜凝乳蛋白酶的人，化学核溶解法是禁忌证。
