| 1. | The rate of chromosome non - disjunction was higher than that of control group from 0
Igy开始引起染色体不分离率较对照增加（尸o |
| 2. | Autopoly - ploids may arise from the fusion of diploid gametes that have resulted from the nondisjunction of chromosomes at meiosis
同源多倍体通常可能来自在减数分裂过程中染色体不分离导致的二倍体融合。 |
| 3. | The effects of low dose ionizing radiation on mitotic chromosome non - disjunction of the cultures were more outstanding than that of the whole blood
结果显示：小剂量电离辐射对有丝分裂染色体不分离的影响是照射培养物比照射全血效果明显；照射全血时，剂量从0 |
| 4. | Aneuploidy the condition , resulting from nondisjunction of homologous chromosomes at meiosis , in which one or more chromosomes are missing from or added to the normal somatic chromosome number
非整倍性：在减数分裂的过程中同源染色体不分离而造成的一条或多条染色体的缺失或增加。 |
| 5. | 05 ) , and had the tendency of increase as dose increased . the rate of chromosome non - disjunction was higher when radiation time was 3 times than that of 1 time at the same dose ( p < 0
0引，并且随照射剂量的增加呈增加趋势；当照射次数增加到3次，染色体不分离率较同等剂量照射1次明显升高（尸0 |
| 6. | 05 ) , and had the tendency of increase as dose increased . when radiation time was added up to 3 times , the rate of meiosis chromosome non - disjunction was significant higher than 1 time at the same dose ( p < 0
05 ） ，并具有随剂量增加而增加趋势；照射次数累加3次后，染色体不分离率较同等剂量照射1次明显增加（尸o |
| 7. | 05 ) , and had the tendency of increase as radiation frequency increased . the effect of low dose ionizing radiation on meiosis chromosome non - disjunction was remarkable from 2 gy ( p < 0
05 ） ，且具有随照射次数的增加染色体不分离增加的趋势；小剂量电离辐射对减数分裂的影响是从zgy开始，染色体不分离较对照增加（尸0 |
| 8. | Chromosome disorders , one of the most important genetic diseases , are the most frenquent cause of mental retardation . these disorders are thus important public health problems for no entirely satisfactory prevention measures now exist
染色体不分离所导致的疾病是最主要的遗传病之一，也是导致智力发育障碍的最主要原因，其发生给社会和家庭带来极大的负担，其中以down综合征( ds )最为常见。 |
| 9. | As life level advancing , the environment around us has being changed . there are more and more radiative materials in our lives . in order to search for environmental factors related with chromosome disorders , a hospital - based case - control study about down syndrome was carried out
论文以ds为例开展了以医院为基础的病例-对照研究，分离导致染色体不分离的可能因素；同时探讨小剂量电离辐射与染色体不分离的关系及其分子机制。 |
| 10. | In the laboratory experiment part , human peripheral blood , cultured cells and icr mice were study objects . the changes of mitotic chromosome numbers were measured by human metaphase chromosome counts and statistic analyzed used x2 - test . the changes of meiotic chromosome numbers were measured by mice one - cell zygote chromosome counts and statistic analyzed usedx2 - test . the effects of low dose ionizing radiation on the expression of topoisomerase ii were measured by immunocytochemistry , western blot and rt - pcr
流行病学结果显示长期小剂量辐射接触与染色体不分离呈正相关，为进一步在细胞遗传学和分子生物学方面研究小剂量电离辐射与染色体不分离关系及其机制，本课题第二部分以外周血、培养细胞、 icr小鼠为研究对象，用外周血染色体计数和单细胞受精卵染色体计数的方法研究小剂量辐射和拓扑异构酶复旦大学2000级博士生学位论文11a抑制剂及其二者的协同效应对有丝分裂和减数分裂染色体不分离的影响，用免疫细胞化学染色、 westernblot 、 rt pcr等方法研究了电离辐射引起拓扑异构酶a表达变化。 |
