One chimaeric mouse was produced by injection of es cells into blastocyst of c57bl / 6j . the chimaeric rate of fur colour was about 15 % . fl generations of germ - transmission derived from es cell were not obtained when chimaeric mouse mated with kunming albino mice and c57bl / 6j mice 将胚胎干细胞注射到c57bl 6j小鼠的囊胚腔内,移植后产生了一只wk2 -胚胎干细胞的雄性嵌合体鼠,毛色嵌合率为15左右,成熟后分别与c56bl 6j和昆明白雌鼠交配,均未得到来自es细胞的后代。