1983 barbara mcclintock 1984 nils kaj jerne denmark 1984年尼尔斯杰尼丹麦
2.
The nobel prize in physiology or medicine 1984 : nils kaj jerne 诺贝尔生理学或医学奖-尼尔斯杰尼
3.
Natural autoantibody ( naa ) refers to antibodies that are present in the surum of healthy individuals in the absence of deliberate immunization with the targeted antigen . previous studies have showed that human immunity system includes a huge and complicated autoantibody repetoire . to date , several hundred naa have been found and proved to exist in normal individuals , including autoantibody targeted rbc , mhc , dna , transferrin , keratin , diphosphatidyglycerd , idiotype of igg , etc . naa , characterized by binding to various and nonspecific antigen , reacting rapidly , keeping conservative relatively , has been widely claimed to be an important constituted component of innate immunity . lt was proposed that the production of naa was related to positive selection of b lymphocytes 对naa的研究表明，健康人体免疫系统中存在着一个庞大而复杂的自身抗体网络。包括抗角蛋白自身抗体( antikeratinautoantibody , akautoab )在内，迄今已经发现并证实的naa有数百种，如抗rbc 、 mhc 、 dna 、转铁蛋白、脂类和多糖的抗体以及jerne免疫调节网络中的抗独特型抗体( anti - idiotypeantibody )等。由于个体出生即有naa ，且naa具有作用范围广、没有特异的选择性、反应出现快、有相对的稳定性等天然免疫的特点， naa被认为是天然免疫( innateimmunity / naturalimmunity )的重要组成部分。
