The ultimate product of the endoperoxide cleavage is a carbon - centered free radical which has functions as an alkylating agent , reacting with both heme and parasite proteins Tanaka等建立了一种新奇、快速、方便的分离药物靶标蛋白基因的疗法： drug - western法。
2.
Lots of pharmacological and clinical experiments indicate that artemisinin is high effective with low toxicity . evidences from many laboratories suggest that the antimalarial function of artemisinin depends on the cleavage of the endoperoxide by binding to intraparasitic heme 虽然目前还没有直接证据表明虫体内蛋白质烷化是虫体致死的原因，但烷化蛋白与青蒿素类药物抗疟作用有关是很明显的。
3.
Artemisinin was originally isolated from artemisia annua , a herb used as the ancient chinese herbal remedy . artemisinin and its derivatives are new types of antimalarial with stable endoperoxide bridges differing from others , for instance chloroquine 青蒿素类药物是一种与已知抗疟药如氯喹等完全不同的新型化合物。大量药理及临床研究证明青蒿素类药物是优于氯喹的抗疟新药，具有速效、低毒、高效等特点。
4.
Artemisinin , a sesquiterpene lactone containing an endoperoxide bridge , is a kind of phytoalexin . sa , a key signal molecular during systemic acquaired resistance ( sar ) , is related to the biosynthesis of phytoalexin . aba , a stress - resistance plant hormone can influence the secondary metabolism to stimulate phytoalexin biosynthesis 青蒿素属于萜烯类化合物(倍半萜类)是植保素( phytoalexin )的一种， sa是植物产生系统获得性抗性的重要信号分子，与植保素的产生相关。
