| 1. | The research team reported for the first time that cftr is detected in both human and mouse sperm
研究人员首次在人类和老鼠的精子发现cftr 。 |
| 2. | 2004 and the role of cftr in fertility and infertility nature cell biology , 2003
, 2004 ）及囊性纤维化跨膜电导调节器（ cftr ）在生殖及不育中的角色（ 《自然细胞生物学》 |
| 3. | Co - culture of sperm with endometrial cells treated with antisense oligonucleotide against cftr , or with bicarbonate secretion - defective cf epithelial cells , resulted in lower sperm capacitation and egg - fertilizing ability
相反，如果用缺乏cftr的细胞，或者是cftr发生突变的细胞，精子便不能有效获能。 |
| 4. | Previous studies by the centre have described the present of this channel in the female reproductive tract and its defect leads to impaired bicarbonate secretion that in turn , affects sperm fertilizing capacity
上皮细胞生物学研究中心较早的研究已证实cftr存在于女性生殖道上，其功能失效可阻止精子在女性生殖道内的获能。 |
| 5. | These results are consistent with a critical role of cftr in controlling uterine bicarbonate secretion and the fertilizing capacity of sperm , providing a link between defective cftr and lower female fertility in cf
由于cftr存在于女性生殖道上，其功能失效可阻止精子在女性生殖道内的获能，因此导致囊性纤维化女性病人的不育。 |
| 6. | Although cftr has been implicated in bicarbonate secretion , its ability to directly mediate bicarbonate secretion of any physiological significance has not been shown . professor chan demonstrates that endometrial epithelial cells possess a cftr - mediated bicarbonate transport mechanism
陈教授与其研究队伍发现， cftr作为一个阴离子通道，可以调节子宫内碳酸氢根（ hco3 - ）的分泌，从而影响精子的受精能力。 |
| 7. | Cftr inhibitor or antibody significantly reduces the sperm capacitation , and the associated hco3 - dependent events . they also found that the fertilizing capacity of the sperm obtained from heterozygous cftr mutant mice is also significantly lower as compared to that of the wild - type
Cftr抑制剂或抗体能有效减低精子获能，及相关的碳酸氢根依赖反应；研究人员又证实cftr突变老鼠，其精子授精能力大大比野生型老鼠为低。 |
| 8. | These results suggest that cftr in sperm may be involved in the transport of hco3 - important for sperm capacitation and that cftr mutations with impaired cftr function may lead to reduced sperm fertilizing capacity and male infertility other than cbavd
研究结果显示，精子的cftr功能为碳酸氢根的传输，促使精子获能；而cftr基因突变引致功能失效，会降低精子授精能力，这是先天性无输精管以外另一导致男性不育的可能因素。 |
| 9. | Cystic fibrosis is caused by mutations in the gene encoding an ion - transport protein , the cystic - fibrosis transmembrane conductance regulator ( cftr ) . defective secretion of anions is the primary cause of many of the clinical manifestations of cystic fibrosis , including pancreatic insufficiency
囊性纤维化是由作为阴离子通道的跨膜电导调节器（ cftr ）的基因突变所致，而阴离子分泌缺损是囊性纤维化的多种临床表现（包括胰腺功能缺陷）的主要原因。 |
| 10. | The present finding also suggests that defects in cftr may affect male fertility to various degrees since near 2000 mutations have been found to be associated with cftr . the present finding may explain many unexplained cases of male infertility and provide new target for diagnosis
研究同时显示cftr缺陷可以对男性不育造成不同程度的影响，目前已知的与cftr相关的基因突变逾2 , 000种，研究结果可能为许多未明原因的男性不育个案提供新的解释，并提供诊断的新靶子。 |
