| 1. | Chordomas are rare malignant neoplasms
摘要脊索瘤是极少见的恶性肿瘤。 |
| 2. | Besides , the treatment of chordomas remains a challenge
脊索瘤之治疗仍是一个很大的挑战。 |
| 3. | Most chordomas are found at skull base , sacrum and cervical spine
大多数脊索瘤发生在颅底、颈椎及荐骨。 |
| 4. | Chordomas are rare tumors of notochordal tissue remnants and most frequently affect the sacrum and skull base
摘要脊索瘤是来自脊索遗迹的罕见肿瘤，主要侵犯荐椎及颅底。 |
| 5. | Discovery and study of novel genes related to chordoma helps to understand the molecular mechanisms better in the development of chordoma
在本研究中我们应用mrna差异显示、 rt - pcr和免疫组化技术对脊索瘤相关基因进行了研究。 |
| 6. | Chordoma , a frequent malignant tumor of bone , is usually adult epithelial tumors arising from embryonic notochord remains of the axial skeleton
脊索瘤是发生于神经轴中线并侵及邻近骨的脊索残留物，是脊柱肿瘤中最常见的一种。 |
| 7. | Chordoma should be included in the differential diagnosis of a dumbbell - shaped mass involving upper cervical vertebrae in patients with long duration of symptoms
若病人在上颈椎呈现哑铃状肿块及患有长期症状时，脊索瘤应列入鉴别诊断中。 |
| 8. | Many published papers discussed its clinic characteristic points , but little is known a - bout the molecular changes in this disease . few protooncogenes and tumor sup - presser genes have been found to be altered in chordoma
因而脊索瘤相关基因研究将有助于脊索瘤基因诊断和基因治疗的进展，从而在分子机制上彻底去除或阻断致病基因的作用，达到治疗脊索瘤的目的。 |
| 9. | We review the literatures of the clinical feature , pathophysiology , treatment modalities and prognosis of chordomas , and also the newest advances of radiotherapy , including proton beam radiotherapy ( rt ) and heavy charged particles rt ( carbon ions ) for treating chordomas
我们回顾文献中有关脊索瘤之临床表现、病态生理、治疗策略及预后，并整理放射治疗之最新进展，包括质子治疗及重粒子治疗如碳离子对脊索瘤之治疗比较。 |
| 10. | Discussion in the process of development , differentiation and metabolism , the differential expression of genes plays a pivotal role . mrna differential display , established by liang and pardee in 1992 , is among the most sensitive methods for the isolation of differentially regulated mrna
经rt一pcr反应筛查17例脊索瘤及其周围正常组织，扩增片段大小与引物设计一致，可见瘤周组织rnf一n基因表达明显增高，而ctc一sodms在肿瘤组织中表达增高。 |
