| 1. | In addition to the classical genomic pathway through nucleus receptors , estrogen can cause to produce some cellular rapid membrane - mediated effects through nongenomic pathway
Er具核、膜双重分布特征。雌激素的作用通过经典的核受体通路和膜受体通路来完成。 |
| 2. | In addition to the classical genomic pathway through nucleus receptors , estrogen can cause to produce some cellular rapid membrane - mediated effects through nongenomic pathway
Er具核、膜双重分布特征。雌激素的作用通过经典的核受体通路和膜受体通路来完成。 |
| 3. | There are a and 3 subunits of estrogen receptor ( er ) subtypes . they are different in their distribution , density and mediated action . er can be expressed in nucleus or in cellular membrane
雌激素受体（ er ）属于类固醇受体超家族的核受体，具有a和日两种亚型，此二者在各种组织分布及密度各异。 |
| 4. | Peroxisome proliferator - activated receptors ( ppars ) are a family of nuclear hormone receptors . ppar superfamily consists of three members : a , 5 and y
过氧化物酶体增殖因子活化受体( peroxisomeproliferator - activatedreceptors ， ppars )是配体依赖的转录因子的核受体超家族成员，由ppar 、 ppar和ppar三个成员组成。 |
| 5. | Within 2h isolation from the follicle 100 % of oocytes underwent germinal vesicle breakdown and both the nucleolus and the nuclear envelope disappeared . after culturing for 6 h , prometaphase occurred in 90 % oocytes
本研究旨在探索一种崭新的、化学试剂诱导去核卵母细胞为核受体的、无透明带的、手工体细胞核移植方法。 |
| 6. | Estrogen receptor ( er ) , an important transcription factor belonging to the nuclear receptor superfamily , plays a key role in reproductive , cardiovascular and central nervous systems and bone tissue
摘要雌激素受体属于核受体超家族成员，是一类重要的核转录因子，它在生殖系统、骨组织、心血管和中枢神经系统中发挥著重要的生理作用，是治疗骨质疏松和乳腺癌的重要药物作用靶标。 |
| 7. | Pka , receptor tyrosine kinase ( trk ) and classical nuclear receptor of gc were not involved in the gc " s activation of mapks the second part studied the nuclear translocation of gc activated mapks , mainly p38 and jnk , with laser confocal microscopy . the results showed that : 1
Gc激活的mapks的激活不需要pka酪氨酸激酶受体trk及经典gc核受体的参与第二部分是研究gc激活的mapks的核转位，主要是p38和jnk ，用激光共聚焦显微镜观察到以下结果： 1 |
| 8. | Estrogen through binding specific estrogen department of physiology 7 receptor ( er ) in nucleus , functions like a nucleus transcription factor and modulates expression of some genes . it has been found that there exist two subtypes of er . there are a and p subunits which are different in their distribution , density and mediated action
雌激素调节神经系统功能往往通过雌激素受体（ estrogenreceptor ， er ）蛋白介导。 er属于类固醇受体超家族的核受体，具a 、 p两种亚型，此二者在各种组织分布及密度泅异。 |
| 9. | The following research areas will be involved in the project : ( 1 ) mechanism of hereditic factors and its function in chinese type 2 diabetes ; ( 2 ) metabolomics on the cell stress and its nutrition intervention in the type 2 diabetes ; ( 3 ) mechanisms of metabolic nuclear receptors in the process of insulin resistance and type 2 diabetes onset ; ( 4 ) roles of signal transduction molecules , lipid metabolic disorder to insulin resistance ; ( 5 ) type 2 diabetes development and role of pathological changes of blood vessels ; ( 6 ) abnormal insulin secretion , apoptosis and type 2 diabetes ; ( 7 ) function of molecular network of type 2 diabetes progression
本项目拟开展以下研究工作： （ 1 ）中国人2型糖尿病发生过程中遗传因素的发现及其作用机制； （ 2 ）细胞应激在中国人2型糖尿病发生过程中的作用机制及其营养干预的代谢组学； （ 3 ）代谢性核受体在胰岛素抵抗和2型糖尿病发病中的作用机制； （ 4 ）细胞信号转导分子、脂代谢紊乱与胰岛素抵抗的关系； （ 5 ） 2型糖尿病发展过程与血管病变； （ 6 ）胰岛素分泌异常、细胞凋亡与2型糖尿病； （ 7 ） 2型糖尿病发生过程中的分子网络与作用机制。 |
| 10. | To search proteins that associate with the mouse mint protein and regulate notch signaling in nuclei , and to study the function and mechanism of mint - mediated transcription repression , yeast two - hybrid assay was used to screen proteins that interact with a fragment of mint ( f5 , amino acids 2226 - 2959 ) . from 4x106 yeast clones transformed with the bait plasmid and a cdna library of 9 dpc mouse embryo , fifty - one were positive for nutritional screening and p - galactosidase assay . restriction digestion identified 10 independent positive clones and these were analyzed by dna sequencing these clones represent 3 correctly fused cdna fragments , which are mint , alpha a - crystallin - binding protein i ( alphaa - crybpl ) , and nuclear receptor co - repressor 1 ( n - corl ) , respectively
鉴于mwt基因编码区较长，共有10799个碱基，故此我们将mint分为六段，分别命名为fi一f6 ，本研究以其中的f5 （ 222e959 ）和f6 （ 296s576 ）片段为研究对象，将h者分别插入pgb盯7载体中，结果显示： mintfs可与核受体辅助抑制因子1阶cori ） ， o晶状体蛋白结合蛋白1hlphatcrybp入及mw加互作用，而f6可与igm的重链恒定区、泛素结合酶2l6和一个未知功能的新的蛋白基因进行结合。 |
