We use collagen and chitosan to make spongy membrane as a dermal substitute in order to develop tissue engineering skin . it is very necessary to investigate the biocompatibility and biodegradation of the couagen - chitosan spongy membrane as an assessment of safety and standardization of a tissue engineering medical product 我们采用胶原和壳聚糖制成的多孔膜作为真皮支架来研制组织工程化皮肤，对胶原一壳聚糖多孔膜进行生物相容性研究和降解研究十分必要，这也是组织工程化产品安全性评价和标准化的需要。
