Mithradates ( c . 131 ? 63 b . c . ) , the great king of pontus and enemy of rome , is said to have swallowed toxic substances systematically , increasing the doses until he made himself im - mune from assassination by poison 据说,伟大的本都国王、罗马的敌人米特拉达梯(约公元前131 ? 63前年)曾有步骤地吞服各种有毒的东西,并不断地加大剂量,直到后来能不被毒药暗杀。