Hypoteserna gr allt ifrn kina till indien , frn persien till egypten och drefter ver medelhavet till europa 有推测说从中国到印度，从波斯到埃及然后横穿地中海到了欧洲。
2.
A c a2 + / calmo dul in - dep endent pro te in kinas e i i ( c amkii ) antagoni st kn - 6 2 ( 5x l0 - ' mol / l ) presented in the intemal solution had no significan effect on the current peaks induced by extracellular nmda ( l0 # mol / l ) , but prevented the inhibitory effect of b on inmda " these results indicate that gcs have rapid , reversible idebitory effects on lnmda intracellular application of b thiough microelectrode had no effect on inmda , howevet , extracellular application of b or b - bsa suppressed peaks of inmda : all these denote b exerts its influence on nmda receptor by cytoplasm membrane mechansms , which is naxnely rapid , nongenomic mechhasms 加有快速、可逆的。非浓度依赖性抑制作用。通过微电极将b直接导入细胞内， inmda不受影响，而胞外给予b或besa ， inmda减小，提示b对nmda受体的调控通过膜机制产生，这种作用与经典的基因组机制不同；因为广谱激酶抑制剂和特异的pka抑制剂均可翻转b的抑制效应， camk11抑制剂也可阻断b的效应，而这些激酶抑制剂本身对inmda即有强烈的抑制作用： pka激动剂本身对inmda无明显作用，也不影响b对l 。
