趋化作用 meaning in Chinese
chemotaxis
Examples
- Taken together , our study suggests that ( - arrestin2 can function not only as a regulator of cxcr4 signaling but also as a mediator of sdf - 1 ( - induced chemotaxis and this is probably via the ask1 / p38 mapk pathway
综上所述， - arrestin2参与介导了cxcr4引起的趋化作用，这种作用可能是通过调节p38mapk / ask1信号通路来实现的。 - Chemotaxis mediated by chemokine receptors , such as cxcr4 , play a key role in lymphocyte homing and hematopoiesis as well as in breast cancer metastasis . we have previously demonstrated that ? - arrestin2 functions to attenuate cxcr4 - meidated g protein activation and to enhance cxcr4 internalization . here we further show that expression of ( - arrestin2 in both hela and hek293 cells significantly enhanced the chemotactic efficacy of stromal - cell derived factor 1 ( ( sdf - 1 ( ) , the specific agonist of cxcr4
- arrestin2是趋化因子受体的一种重要的调节蛋白，本研究工作发现在hek - 293或hela细胞中升高- arrestin2的表达水平会显著增强cxcr4介导的趋化作用，反之当- arrestin2的表达被它的反义核苷酸或rnai所抑制， cxcr4介导的趋化作用则被明显抑制。 - While the suppression of ( - arrestin2 endogenous expression by antisense or rnai technology considerably attenuated sdf - 1 ( - induced cell migration . expression of ( - arrestin2 also augmented chemokine receptor ccr5 - mediated but not egf receptor - mediated chemotaxis , indicating the specific effect of ( - arrestin2
与此相似，另一种趋化因子受体ccr5介导的趋化作用也受- arrestin2的调控，但egf受体介导的趋化作用则不受- arrestin2的调控，说明- arrestin2的作用有一定的受体特异性。