新抗原 meaning in Chinese
neoantigen
Examples
- This modification includes : ( 1 ) selecting two important molecules as candidates , ( 2 ) choosing a promiscuous t - cell epitope , and two b - cell epitopes or conserved amino acid sequences from the two important molecules , ( 3 ) connecting them adequately through analysis by the molecule designing software . therefore , the synthetic new antigen may interfere with the process of fertilization by multiple ways and its contraceptive effects may be enhancing . based on the molecule designing methods , the b - lymphocyte cell epitope of sperm / testis specific protein sp17 and cyritestin which interfere with fertilization in mouse , as well as the promiscuous th cell epitope of the ribonuclease ( rnase ) in bovine were selected
本研究以蛋白质分子设计的理论和方法研究避孕疫苗，将sp17和cyritestin关键表位和牛核糖核酸酶非选择性th细胞表位合理组合，获得新抗原- 35肽序列；并在合成、纯化后分别与弗氏佐剂、免疫刺激复合物( iscoms )混合后免疫不同遗传背景的雌性小鼠，观察血清和生殖道内的特异性抗体滴度的动态变化、生育力的改变以及免疫后小鼠重要脏器的组织病理学改变：以及在ivf下，新抗原的特异性抗血清对精卵相互作用的影响及抗原在精子表面的特异性定位。 - Female mice serum and vaginal secretion antibodies , their fertility and the pathological changes were determined . on the other hand , the effects of the anti - serum against synthetic peptide on the sperm - egg interaction during ivf and the location of p3 peptide in sperm were watched . the main results and conclusions were as follows : 1 ) the new antigen p3 peptide which harvested from the 430a peptide synthesizer were verified by the mass spectrograph and hplc , that the ratio of mass / charge of the synthetic peptide was equal to the molecular weight in theory and its purity was above 95 %
本研究的主要结果和结论如下：一、经抗原分子设计，在430a自动肽合成仪上合成的新抗原p3 ，经质谱仪分析证明其荷质比与理论一致；纯化后，其纯度大于95 ；将新抗原与klh偶连后免疫小鼠，经westernblot证实其诱导的特异性抗体可识别小鼠、大鼠、人睾丸组织中分子量约为22kd和55kd左右的蛋白质。 - Objectives to improve the effect of a single mtb8 . 4 dna vaccine , we constructed a chimeric mtb8 . 4 / hil - 12 eukaryotic plasmid by linkage of mycobacterium tuberculosis mtb8 . 4 gene to human il12 gene with a simple linker ( gly4 - ser ) 3 . we analyzed the immunogenicity of chimeric dna vaccine and investigated the immune responses elicited when mtb8 . 4 / hil12 was presented as endogenous ag
目的：以il - 12作为分子佐剂，与结核杆菌新抗原mtb8 . 4基因连接形成嵌合分子，将其克隆到真核表达质粒中，构建成嵌合dna疫苗，研究其在小鼠体内诱导细胞免疫应答的效果及对c57bl 6n小鼠的免疫保护作用，为寻求安全、有效、廉价的结核病新疫苗打下基础。