抑制位 meaning in Chinese
choke bit
Examples
- The pocket accommodating the aromatic ring of phenylalanine is formed predominantly by hydrophobic side - chains , including those of ile10 , ile13 , prol50 , leul75 , leul79 , phe209 , ser211 and val221 ; whilst the amino group and carboxylate group of phenylalanine is coordinated by asp6 , asp7 , gln151 and ser180 . the n - terminal region is found to be important to the function of arog . point mutation reveals that residue substitution of ilelo to ala10 leads to desensitization in the presence of 1 mm phenylalanine , simultaneously , exhibits a dramatic decrease in enzymatic activity
综合前人的研究和本研究工作的实验数据，得出以下结论： 1 )在arog的反馈抑制位点供苯丙氨酸结合的疏水口袋由asp6 、 asp7 、 ile10 、 ile13 、 pro150 、 gln151 、 leu175 、 leu179 、 ser180 、 phe209 、 ser211和val221等12个氨基酸残基构成； 2 )苯丙氨酸结合的疏水口袋分为两个区域，与苯丙氨酸的苯环发生疏水作用的区域由ile10 、 ile13 、 pro150 、 leu175 、 leu179 、 phe209和val221的侧链构成，而asp6 、 asp7 、 gln151和ser180的侧链构成了与苯丙氨酸的氨基和羧基相互作用的区域。 - In escherichia coli , arog gene encodes phenylalanine - sensitive 3 - deoxy - d - arabino - heptulosonate - 7 - phosphate synthase isoenzyme arog that catalyzes the first committed step of shikimate pathway . here we study the essential amino acid residues involved in the formation of feedback inhibition site of arog , and the effects of n - terminus on feedback inhibition and its quaternary structure , and the importance of the structural " d2 " symmetry to allosteric inhibition
本博士论文工作以大肠杆菌k - 12来源的arog为研究对象，通过定点突变、反馈抑制实验和酶学动力学参数的测定，深入地研究了arog的反馈抑制位点的特性，并对arog的n -末端在反馈抑制机理和维持稳定四级结构中的作用，以及蛋白质结构的“ d2 ”对称性对酶功能的重要性等进行了具体的研究。