tnfa meaning in Chinese
喷嘴总过流面积
Examples
- Tnfa antagonists including mab against tnfa and tnf receptor ( tnfr ) , soluble tnfa receptor ( stnfr ) , mutant tnfa have been applied or tried to apply in the clinical with some positive therapy effects , but there were still some problems to limit the application of these agents
重组tnf及其拮抗剂(包括抗tnf单抗、抗tnf受体单抗、可溶性tnf受体、 tnf突变体)均已应用于临床并取得了一定的治疗效果。 - We hope that our study will provide us with more comprehensive knowledge of the mechanisms of immune regulation and the roles that dc and complement play in innate and acquired immunity , as well as to lay a foundation for further exploration of the roles dc play in antigen - specific immune responses and immune tolerance from a new perspective . part i expression of complement receptors and complement - associated molecules on dendritic cells derived from distinct - origin at different stages of development two subsets of dendritic cells were generated from precursor cells isolated by means of magnetic cell separation system
曰补体受体及其相关分子在modc上的表达不同分化阶段的单核细胞衍生性dc ( monocytes一deriveddc ， modc )的诱导:将新鲜分离的单核细胞mo ，在含有gm一csf和工l一4培养体系中诱导5一7d ，即分化为未成熟modc ;对培养至sd的未成熟modc ，用tnfa刺激zd ，即分化为成熟modc ;此时再用lps刺激24h ，即为活化的modc 。 - After 3 rounds of screening , 10 of 20 clones were identified as positive clones and all the 10 phage clones sharing the same amino acid sequence : ehmaltypfrpp , and these positive 12mer phage clone peptide can bind with tnfa specifically . the results suggests that this method is very specific and simple for screening of binding epitope to small peptide molecule from phage display peptide library
在以噬菌体环七肽tnfa模拟肽克隆刁k naqsoc ）为靶对噬菌体随机十二肽库进行h轮筛选后，挑取20个克隆，经elisa鉴定有10个克隆均与t ’ nfa结合，测序结果显示它们均为同一氨基酸序列： ehmaltypfrpp 。 - Part iv computer - aided molecule modelling of tnfa mimotopes and tnfa - binding peptides : to investigate the interaction between tnfa mimotopes and tnfa - binding peptides , the computational docking program autodock ( with confirming calculations using discover ) was used to predict the binding modes of llt - 18 with tnfa firstly , then lcs - 7 was docked to llt - 18 by manual . the interaction between llt - 18 and tnfa or lcs - 7 showed electrostatic interaction and h - bond dominant
进行对接，对两者间结合位点进行分析；在此基础之上，以insight11软件构建lcs刁分于三维结构， autodock程序对接llt和lcs 7两个短肽分子，找寻两者结合的关键性残基，结果表明llt与tnfa及lcs 7分子间相互作用以静电相互作用为主， lcs刀和tnfa活性部位的arg在分于间相互作用中起重要作用。 - Part ii screening of tnfa mimotopes from phage display peptide library : based on the results of screening tnfa binding - peptides , we have tried to use neutral tnfa mcab j1d9 as target to screen tnfa mimotopes from c7c phage display peptide library , which may be another form of antagonist for tnfa , and the mimotopes were identified by sandwich elisa . after 3 rounds of screening , we got 9 phage clones identified as positive clones which can bind with mcab j1d9 . we also identified the binding between mimotopes and tnf receptor by competitive elisa , and the results showed strongly binding . the amino acid sequence results shown three different sequences : c - rrpaqsg - c - nkhnrki - c and c - rgmsrki - c
在对噬菌体环七肽库进行三轮亲和性筛选后，随机挑选20个噬菌体克隆， elisa鉴定出9个阳性克隆，经dna测序推出三种氨基酸序列： c - rrpaqsg - c 、 c - nkhnrki - c和c - rgmsrki - c ，其中优势克隆序列为c - rrpaqsg - c ；鉴定结果显示阳性克隆能够与tnf受体结合，并且能够阻断tnf与受体的结合，提示筛选得到的环七肽克隆展示肽具有tnf的抗原性及与tnf受体结第一军医大学顾士学位论文合的特性，为tnfa表位模拟肽。