nf-kb meaning in Chinese
核转录
Examples
- Nuclear factor - kb ( nf - kb ) is one kind of cell transcription factor that exist in many kinds of cells in nervous system . it is also has great association with the process of neuronal degeneration and apoptosis . from the above we can see that tbi , secondary brain injury , apoptosis and cytokines associated tightly
细胞核因子b ( nuclearfactor - b , nf - b )是一类普遍存在的细胞转录因子，功能性nf - b复合物存在于神经系统的各种类型的细胞中，包括神经元、星形胶质细胞、小胶质细胞、少突胶质细胞中，在神经细胞变性和凋亡过程中起十分重要的作用。 - Reported that chitosan or oligochitosan can synergistically induces no production by raw264 . 7 cells when the cells are treated with recombinant r - ifn . chitosan or oligochitosan alone has no effect on the production of no . the information above led us to determine whether oligochitosan can enhance no release in macrophages and to further determine whether nuclear factor - kappa b ( nf - kb ) is involved in the course of the activation
Hyung - minkim和hun - taegchung等人则认为壳聚糖或者壳寡糖单独作用于小鼠单核巨噬细胞raw264 . 7 ，不能诱导其产生no和tnf ，但可明显诱导经-干扰素( - ifn )预刺激的巨噬细胞产生no和tnf 。 - The protein level of nf - kb in nucleus peaks at 6 h after stimulation and persists for at least 6 h . pdtc ( pyrrolidinedithiocarbamate ) , an inhibitor of nf - kb , the effective concentration of it for nf - kb inhibition without any toxicity on cells is up to 100 umol / l , can significantly block no production induced by oligochitosan . although the study reported herein reveals that oligochitosan induces no production via nf - kb in macrophage , which is an important signaling mechanism of oligochitosan inducing immuno - enhancement of macrophage in vitro
加入100林mol / l剂量的nf一忍抑制剂毗咯烷二硫代氨基甲酸盐( pnte )作用于rawz “ . 7细胞( 4火10 ，个细胞/ ml ) 90rnin ，然后再加入100林留而剂量的壳寡糖对巨噬细胞进行刺激，发现pdtc在各个时间点( 6 、 12 、 18 、 24h )都明显抑制壳寡糖对巨噬细胞no的诱导作用。 - Comprehensive cellular responses was found in human amnion fl cells following exposure to low concentration of mnng , such as the lowering of dna replication fidelity resulted from alteration of dna polymerase profile ; activation of a lot of transcription factors , such as api , creb , nf - kb etc ; clustering of egfr ( epidermal growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and activation of camp - pka - creb and jnk / sapk signal pathways
我们发现，低剂量mnng处理后的人羊膜fl细胞有广泛的细胞反应，并有多个信号转导通路的激活和基因表达的改变。例如dna复制保真度下降， dna聚合酶谱发生改变，应用报告基因技术和底物磷酸化检出技术证明细胞一系列转录因子如ap1 、 creb 、 nf b等被激活，细胞表面受体如表皮生长因子受体、肿瘤坏死因子受体发生聚簇，细胞信号转导通路camp - pka - creb和jnk sapk被激活。 - The cells were then stimulated with various concentrations and incubation times of oligochitosan to study dose - dependent and time - dependent manners . the effect of oligochitosan on the production of no released by raw264 . 7 cells was evaluated by griess method , which was also used to evaluate the effect of nf - kb inhibitor on no production induced by oligochitosan . western blot was performed to detect the protein content of nf - k b in the nuclear extract
本课题以小鼠单核/巨噬}炎魏细胞raw264 . 7为研究对象，观察壳寡糖单独作用于巨噬细胞对其产生no的影响，并初步探讨了核转录因子一kappab ( nf一kb )在这过程中的作用，旨在部分解释壳寡糖对免疫系统调节作用的机理，为其在医学上的应用提供理论依据。