neurodegeneration meaning in Chinese
神经变性，神经退行性变
神经退行性变
Examples
- It is also important in several types of neurodegeneration and in macular degeneration ( the main cause of blindness in the old )
它对几个类型的神经性退化和黄斑变性（老年人失明的主要原因） ，也很重要。 - Because fddnp - pet binding differentiates among clinical entities with varying severity of cognitive decline , it may eventually prove useful in the early detection of neurodegeneration , they concluded
研究人员总结，因为fddnp - pet能够区分临床上不同程度的认知力减退，它最终可能在神经退行性病变早期诊断中发挥重要作用。 - Excitotoxicity , associated with stroke and neurodegeneration , is triggered primarily by massive ca2 + influx arising from overactivation of glutamate receptor channels of the n - methyl - d - aspartate ( nmda ) subtype . although approaches to treatment of these disorders with antagonists of nmda receptor ( nr ) have been testified to be effective in animal models , successful therapy in humans was limited by the severe side effects of complete nr blockade for their space window and time window
已有的nr受体拮抗剂或阻断剂均为人工合成的小分子药物，能弥散通过血脑屏障(空间窗过大) ，作用选择性低，病变脑区及非病变脑区都会受到影响，而且由于神经元可逆性损害的“时间窗”极短，人们难以适时使用有效的神经保护药物，这些均导致已有的药物难以进入临床。 - [ note : in neurodegeneration the main aggregates tend to form in other parts of the cell than the lysosome , but there is good evidence that this is a compensatory measure when neurons ' lysosomes stop working properly as a result of the more modest accumulation of lysosomal toxins , so if we fix the lysosome then the non - lysosomal aggregates should disappear naturally
[附注：在神经性退化中，主要的堆积物往往在细胞的其他部分形成、而不是在溶酶体形成，但有很好的证据表明，这是一种补偿措施：当神经原的溶酶体因溶酶体毒素积累到一定程度就停止工作，所以，如果我们修理了溶酶体，那么非溶酶体的堆积物就会自然消失。 - It may have a preventional function from alzheimer ' s disease . molecular biological studies are shown that apoe isoform has a isoform - specific role to neurodegeneration . apoe3 and apoei aid to sustain the stabilization of cytoskeleton protein tau , while apoe4hyperphosphorylates tau to destabilize the microtubule protein , which will make neurocyte easy to form neurofibrillary tangles in ad
分子生物学研究发现， apoe异构体对神经细胞退化表现出异构体特异作用， apoe _ 3和apoe _ 2有助于维持微管的稳定性，而apoe _ 4则使tau蛋白超磷酸化，破坏微管的稳定性，使神经细胞易于形成神经纤维缠结。