| 1. | In the recent decade , more and more attention has been paid to the roles of acetylation in transcription regulation
尤其是近十多年来，乙酰化在真核生物基因表达调控中的作用日益受到人们的关注。 |
| 2. | Combined with the results of histone deactylase inhibitor , it is suggested that histone acetylation plays an important role in hsp gene transcription regulation
结合以上去乙酞化酶抑制剂的实验结果，我们认为组蛋白乙酞化修饰参与了热休克基因的表达调控。 |
| 3. | The mechanisms of acetylation in transcription regulation are unclear , and the role of the acetylation in hsp gene transcription regulation is still a disputed issue
一直以来，乙酰化是否参与热休克基因表达调控以及乙酰化在基因调控中的作用机制都存在争议。 |
| 4. | The study on the relationship between the acetylation and hsp gene transcription regulation will help us in understanding the mechanisms of eukaryotic transcription regulation
因此，对乙酰化与热休克蛋白基因表达调控关系的深入研究，将有助于我们对乙酰化参与的真核生物基因表达调控的理解。 |
| 5. | Promoter prediction is an essential task in the research of transcription regulation , but computational prediction of promoters has been one of the most elusive problems despite considerable effort devoted to the study
摘要启动子预测是研究基因转录调控的重要环节，但现有算法的预测正确率偏低。 |
| 6. | The identified proteins are involved in a variety of cellular process including several zinc finger proteins relevant to transcription regulation , such as zinc finger 198 , 263 , 14 , 224 , zf6 , novel protein similar to transcriptional represser ctcf , and kruppel - like zinc finger protein ; two members of the adams ( a disintegrin and metalloprotease domain ) family ; two members of integrin family ; several proteins involved in the signal transduction , cell - cycle control , chromatin remodeling and transcription repression ; and also some proteins of cell skeleton and some with unknown functions
鉴定出的蛋白包括多个与转录调控相关的锌指蛋白，如锌指蛋白198 、 263 、 14 、 224 、 zf6 、转录抑制因子ctcf样蛋白、幻肚pple样锌指蛋白等:两个含金属蛋白酶结构域和整合素结合结构域的家族成员adam28和adam17 ;两个整合素家族成员pz整合素和含十个egf样结构域的整合素( tied ) ;与细胞信号转导通路有关的蛋白;与细胞周期调控有关的蛋白;与染色体重塑和基因转录抑制有关的蛋白;细胞骨架蛋白以及其他功能未明的蛋白等。 |
| 7. | In this thesis , we studied the effects of acetylation on hsp gene transcription regulation in drosophila melanogaster , in an attempt to disclose the mechanisms of the acetylation in hsp gene inducible transcription , at both the molecular and the chromosomal levels . the main results and conclusions are as followings
本文以黑腹果蝇为实验材料，从不同角度研究了乙酰化修饰与热休克基因表达调控的关系，并对乙酰化修饰在热休克基因的诱导表达中的作用机制进行了探讨，建立了分子水平与染色体水平上的联系。 |
| 8. | In summary , we constructed and characterized a bac library of silky , a unique chinese native breed of chicken . the library has high genome coverage ( 13 - fold ) , chimerism ( 6 % ) and overlapped bacs , which made it a valuable resource to complete chicken physical map , study functional genes and construct bac contigs . we analyzed the whole genomic sequence and snps of tyrp1 and found that silky tyrp1 is different with other breeds both in microsatellite and transcription regulation site
中国农业人学博卜学位论文摘要本研究构建了中国特有鸡种丝羽鸟骨鸡基因组bac文库并进行了文库质量鉴定，它所具有的13倍高基因组覆盖率、 6 %的嵌合率和部分重叠的克隆使其成为完善鸡的基因组图谱、研究基因功能和构建bac重叠群的优质资源。 |
| 9. | Aes contains a glutamine - rich ( q ) domain in its n - terminal , which sharing high homology with the amino terminal region of groucho / tle ( transducin like enhancer of split ) . the function of aes is not clear yet , while groucho / tle were found to be a family of transcription co - repressor and play impo rtant roles in notch signaling , wnt - 0 catenin signaling and other transcription regulation events
Aes的n -末端约130个氨基酸中富含谷氨酰眩( q )残基，形成一个q结构域，与转录协同抑制分子tle ( transducinlikeenhancerofsplit )的氨基端高度同源。 |
