Ie acts as a general gene transcription activator . it consists of dna - binding domain and acid amino acid transcription activate domain . what kinds of promoter can be stimulated by ie 180 另外ie180与hsv的立即早期蛋白icp4有较大的同源性,研究ie180转录调控作用有利于疱疹病毒转录调控模型的建立。