霉菌素 meaning in English
mycomycin
Examples
- For the treatment of superficial infection of griseofulvin drugs ; for the treatment of deep infection of drugs such as nystatin
用于治疗浅部感染的药物有灰黄霉素等；用于治疗深部感染的药物有制霉菌素等。 - Inhibitors of cyp51 , such as azalanstat ( rs - 2i607 ) and rs - 2i745 , could inhibit the synthesis of ff - mas to decrease the accumulation of ff - mas . inhibitor of a14 - reductase , such as ay9944 - a - 7 , could inhibit the metabolism of ff - mas to increase the accumulation of ff - mas ; and some other reagents , such as nystatin , could combine with the downstream intermediate in the cholesterol biosynthesis pathway to accumulate mas . in this study , we investigated the role of mas by using these reagents to change the level of endogenous ff - mas
抑制cyp51酶的抑制剂，如azalanstat ( rs - 21607 )和rs - 21745等，均能抑制mas的合成，降低mas的积累；而抑制14 -还原酶的抑制剂，如ay9944 - a - 7等，能抑制ff - mas向t - mas的转化而造成ff - mas的积累；还有一些物质，如制霉菌素，能阻止mas向下游的代谢而造成其积累，本文主要通过应用这些物质降低、或增加组织细胞中内源性mas的积累，来研究mas的作用。 - Using the mouse fetal ovary serum - free culture model , fetal ovaries from 14 day post coitus ( 14 dpc ) mouse were cultured , and treated by ay9944 - a - 7 , nystatin and rs - 21745 . the results showed that 0 . 025 , 0 . 0625 and 0 . 125 um ay9944 - a - 7 or 25 , 50 and 75 iu / ml nystatin increased the total number of follicles per ovary significantly ; however , ay9944 - a - 7 and nystatin at the same doses could n ' t cause the same effect on the number of growing follicles and the average diameter of five largest follicles per ovary . 50 u . m rs - 21745 decreased the total number of follicles , the number of growing follicles and diameter of follicles per ovary significantly after 48 h
首先利用小鼠胚胎卵巢的体外无血清培养模型，培养妊娠14天( 14daypost - coitus , 14dpc )小鼠胚胎卵巢，分别添加能促进mas积累的ay9944 ，制霉菌素，和能抑制mas产生的rs - 21745进行处理，结果表明： 0 . 025 、 0 . 0625利0 . 125 m的ay9944 - a - 7与25 、 50和75iu ml的制霉菌素能显著提高卵巢中形成卵泡的总数量，但是对生长卵泡数和卵泡直径的作用不同；而mas合成抑制剂rs - 21745能够显著降低形成卵泡的总数量。