钙调神经磷酸酶 meaning in English
calcineurin
Examples
- The activity change of uterine smooth muscle can for all - level - age rats
不同年龄大鼠子宫平滑肌钙调神经磷酸酶活性变化 - Inositol 1 , 4 , 5 - trisphosphate receptor involved in the activation of calcineurin signaling pathway in myocardium
三磷酸肌醇受体参与心肌钙调神经磷酸酶信号通路的激活 - Study of the alteration of calcineurin activity regulated by cyclosporine a in vital organs of 1k1c renal hypertensive rats
对肾性高血压大鼠重要脏器钙调神经磷酸酶活性的调控 - Elevation of intracellular calcium ions may be partly induced by increased influx through sarcolemma l type - calcium channels . intracellular calcium elevation , on one hand , would activate calpain , a calcium - dependent cysteine protease that degrade the myofibrillar proteins and cause muscle atrophy ; on the other hand , result in activation of calcineurin which enhance the activity of mhc i promoter and inhibit a shift of mhc isoforms from slow to fast in soleus
这样，可能使得萎缩比目鱼肌细胞内钙离子水平升高，细胞内钙离子静息浓度的增加一方面激活calpain ，增加收缩蛋白的降解，使肌肉萎缩；草四军医大月卜祠成士学位论文另一方面通过激活钙调神经磷酸酶，增加快型mhc基因的表达，使骨骼肌肌球蛋白重链( mhc )发生由慢型向快型的转化。 - To neutralize the function of cam , the cam binding domain peptide from bovine calcineurin a subunit was chosen because the pre - experiment demonstrated that bovine calcineurin could bind to calmodulin strongely in an acidic and high calcium concentration condition which is similar to the cell wall environment . in order to increase the binding ability of the chimeric secreted calmodulin binding peptide , the plasmid containing two copies of calmodulin binding domain were constructed
它共有26个氨基酸，具有信号肽的典型特征。为了削弱质外体cam的功能，选择了牛脑钙调神经磷酸酶can ( calcineurin )的a亚基的cam结合域。预实验结果表明，在近似于胞外环境的酸性高钙条件下can与cam有强结合。