药石罔效 meaning in English

can't be cured by medicine; all medical treatment has failed.; all medicines have failed to effect a cure.; all medicines were tried and found useless.; be past treatment; even medicine fails to make one feel better.; medicines produce no effect.; no medicines [drugs] were of any avail.; one's illness seemed beyond the art of the leech and drugs seemed of no avail.; one was treated by the doctors with every available medicine, but without success.; the remedy proved to be quite ineffectual