致瘤性 meaning in English
oncogenesis
oncogenicity
tumorigenicity
Examples
- Standard test method for oncogenicity study in rats and mice
老鼠和小家鼠致瘤性研究的标准试验方法 - Standard guide for performance of lifetime bioassay for the tumorigenic potential of implant materials
植入物潜在致瘤性的使用期生物鉴定性能的标准指南 - The env protein deduced from env gene encodes the hydrophilic surface protein ( su ) and the hydrophobic transmembrane domain ( tm ) that determine the specific interaction between virus particles and cell surface receptors during retroviral entry . the su of retroviruses is a highly variable genetic element , containing receptor binding sites and major antigenic determinants . exjsrv - specific dna probes were derived . by using these dna probes in tissue hybridization . we successfully identified jsrv mrna expression and proviruses dna in sheep lung tissues infected with jsrv and control group has no postive signals , validating the use of exogenous virus - specific dna probes in the analysis of oncogenic proviral integration sites and identification of integrated exogenous proviral sequences
用地高辛随机引物法标记exjsrv特异的env片段，制备探针，原位杂交检测spa肺组织中的rna及前病毒dna ，结果表明spa患羊肺组织内有jsrvenv基因mrna的表达，同时也检测到了前病毒dna ，而相应的阴性对照却无阳性信号，证实外源性病毒特异的dna探针在致瘤性前病毒的整合位点和整合的外源性前病毒的检测中具有可信度。 - The comparative analysis of sequences indicated that the sequences of meq in different pathotypes are relatively conserved and the homology of the amino acid sequences is very high . the significant differences include two mutations in both mdv - 1 vaccine strains cvi988 / rispens and 814 strain : the deletion of a proline ( no . l93aa ) , and this mutation is just exactly located in a 15 - amino - acid ( eelcaqlcstppppi ) repeat sequence within the c - terminal transactivation domain of meq protein ; and a point mutation with a shift from alanine ( a ) of all virulent strains to serine ( s ) was occurred on the no . 71 aa
结果发现， mdv不同致病型的meq基因序列相对比较保守，它们相互间核苷酸和氨基酸序列的同源性均很高；但是，与所有七个致瘤性的mdv毒株相比，二个型弱毒疫苗cv1988 rispens株和814株均出现了两个特征性的突变：即第194位的p缺失性突变和第71位氨基酸由a变成了s的位点突变；缺失性突变恰恰位于meq基因中转录激活域内的一个多脯氨酸的重复序列( pppp )之中。