自磷酸化 meaning in English
autophosphorylation
Examples
- Gfral is an extracellular protein that is attached to the outer cell membrane by gpi - anchor and could not transducted signalling directly . according to the original model , a gdnf dimer first binds to either monomeric or dimeric gfral , and the gdnf - gfral complex then interacts with two ret molecules , thereby inducing their homodimerization and tyrosine autophosphorylation
传统观点认为： gdnf首先与gfr 1结合形成gdnf - gfr 1复合物，此复合物再与ret结合形成三聚体复合物，引起ret的二聚化，并引起酪氨酸残基自磷酸化，从而引起下游的信号转导。 - Ngf binding to trka receptors results in receptor dimerization and kinase activation . recent evidence supports that not all extracellular subdomains are responsible for receptor activation . structure based drug design for neurotrophic agonists with small molecular weight relies on knowledge of the interaction of neurotrophin with their receptors
Trka在ngf作用下发生二聚化，使胞内域中酪氨酸激酶区激活，从而使trka中酪氨酸自磷酸化，并进一步激活胞内信号转导通路，从而实现神经营养信号传递。