脱氢皮质酮 meaning in English
dehydrocorticosterone
Examples
- Which may provide the molecular basis for the inberine regulation of ll p - hsdl expression by glucocorticoids . secondiy , the regulation of l l 9 - hsdl expression and redutase activity by glucocorticoids was investigated in the primny cultured human chorionic trophoblast
整个妊娠过程中胎盘11 - hsd活性以氧化酶为主，使母体gc在进入胎儿循环前大部分被转化为无活性的17 -羟- 11 -脱氢皮质酮，保证胎儿正常发育所需的激素浓度。 - The co - expression of l l6 - hsd1 and gr in the saxne chorionic trophoblast suggests possible intrcrine achons ofglucoconicoid generated by l l6 - hsdl within the cells . 2 . ewe radiomctric conversion assay showed that trctrient of the cells with the synthetic glucocorticoid - - dexarnethasone ( l0 - ' m ) for 24h increased the conversion of conisone to cortisol , and thes increase was blocked by the gr antagonist ru486
双标免疫组织化学染色结果显示11p hsdi和gr共存于同一个滋养层细胞，提示在体内无活性的gc代谢产物?一17羟d脱氢皮质酮经11p hsdi还原活化后可以直接与同一个细胞内的gr结合，即以内在分泌（ intracrine ）形式发挥作用 - The 11 - hsd1 expression in the fetal brain also gradually increases with gestational age at late gestation and continues to increase in the hippocampus after birth until the 15th postnatal day , which shows a pattern very similar to th secretion . furthermore , previous data show injection of thyroxine ( t4 ) to normal newborn rats up - regulates gr expression in the hippocampus . these data suggest that the role of th in neural development may be partially ( if not all ) accomplished through regulating gc ' s activity
在海马结构， 11 - hsd1与gr共存于同一海马神经元内，主要呈现还原酶的特性，能使无活性的11 -脱氢皮质酮( a )可的松( e )转化为有活性的皮质酮( b )皮质醇( f ) ，从而提高组织局部的糖皮质激素浓度，这样， 11 - hsd1的存在就为亲和力较低的gr发挥作用提供了前提条件。 - L l6 - hsd2 is localized to the sppytiotrophoblast of the placenty providing a fimctional barrier protecting the fetus from matemal glucocorticoids . a sequence resembling glucocorticoid response element ( gre ) has been identified in the promoter region of the human l l0 - hsdl gene . glucocorticoids have been shown to induce the expression of 11p - hsdl in the hippomus in vitro " whereas controversial results were obtained in the hepatocyte
体内至少存在两型11 - hsd ，在细胞完整的状态下， 11 - hsd1主要为还原酶，它活化gc的代谢产物17 -羟- 11 -脱氢皮质酮(啮齿类为脱氢皮质酮)为有活性的皮质醇(啮齿类为皮质酮) ，而11 - hsd2为氧化酶，它催化皮质醇为无活性的17 -羟- 11 -脱氢皮质酮，因此11 - hsd1加强gc的作用，而11 - hsd2减弱gc的作用。