显性失活突变 meaning in English
dominant negative mutation
Examples
- 3 . overexpression of wide - type smads resulted in up - regulation of axudl mrna expression in hepg2 cells , whereas axudl mrna expression was compromised by dominant - negative smad3 ( d407e )
3 .野生型的smad3的过表达能上调h即g2细胞中axudl基因mrna的表达，而smad3蛋白的显性失活突变子smad3 ( d4o7e )却下调其表达。 - Further analysis reveals that expression of ( - arrestin2 strengthened cxcr4 - mediated activation of both p38 mapk and erk and the suppression of ( - arrestin2 expression blocked the activation of two kinases
进一步的研究发现， - arrestin2可以增强cxcr4介导的erk及p38mapk的激活，但只有p38mapk的特异性抑制剂及显性失活突变体才可以阻断- arrestin2对趋化的增强作用。 - Interestingly , inhibition of p38 mapk activation ( but not erk activation ) by its inhibitors or by expression of a dominant negative mutant of p38 mapk could effectively block the chemotactic effect of ( - arrestin2
P38mapk上游激酶ask1的显性失活突变体也可以阻断- arrestin2对趋化的增强作用。这说明是p38mapk而不是erk信号通路与- arrestin2对趋化的增强作用相关。