抗原特异性 meaning in English
antigenic specificity
Examples
- Preparation of specific antibodies against recombinant em18 antigen and detection of the circulating antigen
18重组抗原特异性抗体的制备及对循环抗原检测的初探 - Backgroud : the activation of antigen - specific t cells plays a vital role in the initiation and development of some immune - related diseases , such as transplant rejection and allergic diseases
背景：抗原特异性t细胞的活化在一些免疫相关疾病(如移植排斥反应、变应性疾病)的发生、发展中起着主导性的作用。 - A strong protein band of molecular mass estimation 50 - 54ku with sds - page was seen . this protein was detected on western blots and dot - elisa probed with anti - csfv serum , but p . pastoris gs115 without recombinant e2 showed no protein in this region
表达产物经sds - page和western - blot和dot - elisa分析，确定其表达的融合蛋白分子量大小为50 - 54ku ，且具有天然蛋白的抗原特异性。 - Dendritic cells ( dc ) is the most powerful apc , which can markedly increase the antigen - presentation capacity by maximizing the pepitide - mhc complexes on the cell surface and upregulating the co - stimulatory ligands b7 - 1 and b7 - 2 , adhesion moleculees such as il - 12 that promote full activation of lymphocytes . full activation of antigen - specific t cells requires two signals - one signal coming via the tcr and the other signal through engagment of co - stimulatary molecules . t cells receiving one signal via their tcr are turned off by mhc ( major histocompatibility complex ) , via t cell cd28 binding to b7 on the dc induce tlymphokine and t cell proliferatiion
T细胞介导的细胞免疫在控制肿瘤生长方面发挥着重要作用， t细胞在发挥抗瘤效应(分泌细胞因子和直接杀伤)之前必须先经过活化，体内专职抗原提呈细胞( apc )细胞并使其活化，树突状细胞( dendriticcell , dc )为t细胞的激活提供双重信号， t细胞借助tcr识别由dcmhc分子递交的抗原肽后，通过tcr - cd3复合体传递抗原特异性识别信号(第一信号) ，以cd28为主的t细胞表面辅佐分子识别dc表面b7分子，传递非特异性协同刺激信号(第二信号) ，在机体抗肿瘤免疫应答中处于核心地位。 - In view of the common property of dendritic cells and complement , namely their ability to link innate and acquired immunity , and with no reports , to date , addressing the direct effects of complement on the biological functions of dendritic cells , we decided to study the interaction between the complement system and dendritic cells
本研究的完成有助于在免疫应答的调控机制方面获得新的认识，并对补体和dc在连接天然免疫和获得性免疫之间的作用及相互关系能有更全面的理解，为进一步从新的角度和思路深入研究dc在抗原特异性免疫应答与免疫耐受中的作用及其机制奠定基础。