恒定区 meaning in English
c region
constant regions
region of constancy
Examples
- Huctla4 - lg , " one of the most potent in1n1unosuppressive molecules , is a soluble recombinant fusion protein ( molecu1ar weight of approximately 92 kd ) consisting of the extracellular domain of human ctla - 4 and a fragment ( hinge and constant region ) of the fc portion of human iggl . it strongly adheres to the b7 molecule to block the cd28 - mediated costimulatory signal , resulting in inhibition of in vitro and in vivo immune response
可溶性重组融合蛋白huctla4 - ig是一种新颖的免疫抑制剂，分子量约为92kd ，由人ctla - 4分子的胞膜外区与人igg1的fc段(铰链区与恒定区)融合形成，能牢固地与b7分子结合，阻断cd28介导的共刺激信号，导致免疫反应的抑制。 - To search proteins that associate with the mouse mint protein and regulate notch signaling in nuclei , and to study the function and mechanism of mint - mediated transcription repression , yeast two - hybrid assay was used to screen proteins that interact with a fragment of mint ( f5 , amino acids 2226 - 2959 ) . from 4x106 yeast clones transformed with the bait plasmid and a cdna library of 9 dpc mouse embryo , fifty - one were positive for nutritional screening and p - galactosidase assay . restriction digestion identified 10 independent positive clones and these were analyzed by dna sequencing these clones represent 3 correctly fused cdna fragments , which are mint , alpha a - crystallin - binding protein i ( alphaa - crybpl ) , and nuclear receptor co - repressor 1 ( n - corl ) , respectively
鉴于mwt基因编码区较长，共有10799个碱基，故此我们将mint分为六段，分别命名为fi一f6 ，本研究以其中的f5 （ 222e959 ）和f6 （ 296s576 ）片段为研究对象，将h者分别插入pgb盯7载体中，结果显示： mintfs可与核受体辅助抑制因子1阶cori ） ， o晶状体蛋白结合蛋白1hlphatcrybp入及mw加互作用，而f6可与igm的重链恒定区、泛素结合酶2l6和一个未知功能的新的蛋白基因进行结合。