底物磷酸化 meaning in English

substrate phosphorylation

Comprehensive cellular responses was found in human amnion fl cells following exposure to low concentration of mnng , such as the lowering of dna replication fidelity resulted from alteration of dna polymerase profile ; activation of a lot of transcription factors , such as api , creb , nf - kb etc ; clustering of egfr ( epidermal growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and activation of camp - pka - creb and jnk / sapk signal pathways
我们发现，低剂量mnng处理后的人羊膜fl细胞有广泛的细胞反应，并有多个信号转导通路的激活和基因表达的改变。例如dna复制保真度下降， dna聚合酶谱发生改变，应用报告基因技术和底物磷酸化检出技术证明细胞一系列转录因子如ap1 、 creb 、 nf b等被激活，细胞表面受体如表皮生长因子受体、肿瘤坏死因子受体发生聚簇，细胞信号转导通路camp - pka - creb和jnk sapk被激活。