嵌合分子 meaning in English
chimeric molecule
Examples
- Based on the structure and function analysis of hirudin , a potent thrombin inhibitor , and some platelet aggregation inhibitors , which contain the recognition sequence argglyasp as their functional motif , two chimeric antithrombotic molecules were designed by introducing rgd sequence to hirudin cterminus . these chimera genes were constructed by pcr and inserted into the expression vector pet21a , the constructs were confirmed by restriction enzyme digestion and dna sequence analysis . these recombinant plasmids were transformed into
经限制酶消化和dna序列分析，证明两种重组质粒与设计完全一致。由于rgd -水蛭素嵌合基因上游连接了金黄色葡萄球菌蛋白a spa的信号肽序列，在iptg诱导下两种嵌合分子都获得了分泌表达，表达产物主要集中在细胞周质空间。 - Objectives to improve the effect of a single mtb8 . 4 dna vaccine , we constructed a chimeric mtb8 . 4 / hil - 12 eukaryotic plasmid by linkage of mycobacterium tuberculosis mtb8 . 4 gene to human il12 gene with a simple linker ( gly4 - ser ) 3 . we analyzed the immunogenicity of chimeric dna vaccine and investigated the immune responses elicited when mtb8 . 4 / hil12 was presented as endogenous ag
目的：以il - 12作为分子佐剂，与结核杆菌新抗原mtb8 . 4基因连接形成嵌合分子，将其克隆到真核表达质粒中，构建成嵌合dna疫苗，研究其在小鼠体内诱导细胞免疫应答的效果及对c57bl 6n小鼠的免疫保护作用，为寻求安全、有效、廉价的结核病新疫苗打下基础。