嵌合dna meaning in English

chimeric dna

Objectives to improve the effect of a single mtb8 . 4 dna vaccine , we constructed a chimeric mtb8 . 4 / hil - 12 eukaryotic plasmid by linkage of mycobacterium tuberculosis mtb8 . 4 gene to human il12 gene with a simple linker ( gly4 - ser ) 3 . we analyzed the immunogenicity of chimeric dna vaccine and investigated the immune responses elicited when mtb8 . 4 / hil12 was presented as endogenous ag
目的：以il - 12作为分子佐剂，与结核杆菌新抗原mtb8 . 4基因连接形成嵌合分子，将其克隆到真核表达质粒中，构建成嵌合dna疫苗，研究其在小鼠体内诱导细胞免疫应答的效果及对c57bl 6n小鼠的免疫保护作用，为寻求安全、有效、廉价的结核病新疫苗打下基础。