基因破坏 meaning in English

gene disruption

At present , there are several approaches to targeted gene disruption ( or gene targeting , as it ' s usually called ) that can be customised to attack anywhere in the genome , but they ' re all highly error - prone , disrupting other locations a great deal
目前，有几种方法可用于打靶的基因破坏（或称基因打靶，实际名称也是这样），它可以定制，用来攻击基因组的任何地方，但它们全都容易出错，在非常多的地方破坏其他位点。
Quinic acid , used shikimate pathway in e . coli , it is necessary to extend metabolic pathway by introduction of a heterogenous gene qutb into the host cell . double specific enzyme genes arog , qutb or three ones arog , qutb , arob were co - expressed in a single plasmid pbv220 to improve the enzymes " rate - limiting reactions . modifications of e . coli chromosome by both disruption of the arod gene and directed - site insertion of the arob gene resulted in the change of carbon flow redirected into the quinic acid biosynthesis branch
利用大肠杆菌莽草酸途径合成新的代谢物奎尼酸，须在宿主细胞引入异源酶基因扩展代谢途径；串联表达酶基因，同时适量增加不同种属的多个关键酶酶量，改善限速反应；利用同源重组进行基因整合和基因破坏，改造染色体结构定向改变微生物代谢途径；目的是将碳代谢流最大程度的引向奎尼酸生成的方向。