共刺激分子 meaning in English
costimulating molecule
Examples
- Effects of radix astragali injection on apoptosis of lymphocytes and immune function in patients with systemic lupus erythematosus
细胞亚群及共刺激分子表达与系统性红斑狼疮免疫病理的关系 - Unfortunately , tumor cells can secrete immunosuppressor factors ( such as il - 10 , tgf - p , vegf ) to interfere with dc maturation and function . to overcome tumor - mediated inhibition of dc maturation and function in vivo , immunopotentiating cytokines ( such as il - 7 , il - 12 ) were used for gene - modification of dc , which has proven to be an efficient way to treat cancer in animal models
虽然有直接瘤内注射dc诱导抗肿瘤免疫效应的报道，但肿瘤局部往往是一个处于高度免疫抑制状态的微环境，肿瘤细胞分泌的可溶性介质（如ill 、 tgf卜vegf等）能抑制dc的分化成熟，下调dc表面共刺激分子的表达和iliz的分泌，从而抑制dc的抗原提呈功能，亦对t细胞功能有显著的抑制作用。 - Methods employed to prepare vaccine include rumor cells genetically modified with cytokines , costimulatory molecules and tumor antigenic peptides , dendritic cells ( dc ) primed with tumor antigens in vitro or genetically modified with tumor antigens , or fusion of tumor cells with antigen presenting cells ( apc )
现有的比较受到关注的制备肿瘤疫苗的方法有各种细胞因子、共刺激分子、肿瘤抗原肽等基因修饰的肿瘤细胞疫苗；体外抗原致敏的或肿瘤抗原肽基因修饰的树突状细胞疫苗；肿瘤细胞与抗原递呈细胞融合疫苗等。 - On the other hand , there is substanial evidences tha dcs mediate tolerane . the gm - csf - stbolated mouse bone mwderived mhc class ii + dc progendors tha are deficient in cell surface erpression of the costbolatory molecules b7 - l and b7 - 2 can induce alloanginspecific t ceil anergy in vbo . systendc adchstraion of these donor - derived dc progendors to recipients intravenously 7 days before transplantation prolonged the median graft survival tane from 9 . 5 days to 22 days wbout additional twnosuppressions in a mouse cardinc twlanation model
1995年， lul等报道表面缺乏共刺激分子，特别是缺乏cd80 ( b7 - 1 )和cd86 ( b7 - 2 )的未成熟型dc能在体外诱导同种抗原特异性的t细胞无能，而对dc的适当处理能够使未成熟型dc潜在的耐受原性得以放大和增强，使得dc在诱导免疫耐受中具有相当重要的作用及潜在的应用价值。