ndrg meaning in English
绿龙巢穴
Examples
- Induction of apoptosis of hepg2 cells by ndrg
2凋亡的诱导作用 - Ndrg2 protein has no homology region with any other proteins whose functions are clear either in nucleic acid or in amino acid sequences
由于ndrg家族在基因和氨基酸序列上不与任何已知功能的蛋白质同源。 - The first member be found ofndrg gene family is ndrgl , which was isolated as a new gene upregulated in n - myc mutant mouse embryos and ft is repressed by n - myc and c - myc
Ndrg基因家族中最早被发现的是ndrg1 ，它是在研究n - myc下游调节基因时从小鼠胚胎中发现的一种新基因。 - The expression of ndrg protein family is regulated by lots of intracellular and extracelluar factors . ndrg1 protein expression is upregulated by homocystein > tunicamycin and p53 . in addition , the expression is also activated when differentiation is induced by chemicals such as retinoic acid or when cells are under oxidative stress conditions caused by hypoxia > nickel and other reductive agents
Ndrg家族的表达受很多内外界因素的调节，上调ndrg1的有：第四军医大学硕士学位论文hoidocystcin 、 tillllcmpcin 、细胞氧化应激（缺氧、 np 、各种还原试剂l视黄酸、 p53等；下调的有： nrgen 、 c illyc 、 ump等。 - On the other hand , the expression is repressed by the proto - oncogenes n - myc and c - myc , and in some cases the expression is also repressed by testosterone or dihydrotestosterone ( androgen ) at mrna level infering from all the references that can be obtained , the functions of ndrg family may be involved in cellular differentiation events > maintaining the balance of cell redox potential ( in oxidative stress condition or biological conversion process ) , or counteracting cell malignant transformation , and so on
综合己有的文献，推测ndrg家族可能参与细胞生长分化、维持细胞氧化还原电势平衡（氧化应激或生物转化） 、阻止肿瘤细胞恶化等。因此，研究其在细胞中的具体功能以及可能的信号通路将具有非常重要的意义。深人研究ndrgz在体内的组织细胞和亚细胞水平分布特点及其功能，需要高效价和高特异性的ndrgz抗体。