fgf1 meaning in English
《英文MSH词典》FGF1
[入口词] FGF1
[主题词] Fibroblast Growth Factor 1
[英文释义] A 17 kD single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of ANGIOGENESIS. It binds to HEPARIN,which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages,and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
Examples
- as a member of this superfamily, human acidic fibroblast growth factor ( afgf or fgf1 ), expressed by a variety of cells from all three germ layers, shows great potential for clinical applications for therapy of a variety of diseases, such as parkinson's disease, spinal cord contusion injury, neural regeneration in reimplantation of broken-off finger, brain ischemia, renal ischemia, myocardial infarction, occlusive vascularitis, retinal ischemia, gastric ulcer and nonhealing wound and so on
人类酸性成纤维细胞生长因子(afgf，fgf-1)是成纤维细胞生长因子超家族成员。来自于三个胚层的多种细胞都可以表达afgf。afgf在治疗帕金森综合症、急性脊柱扭曲性损伤、断指中神经功能重建、脑缺血、肾缺血、心肌梗塞、闭塞性脉管炎、视网膜缺血、胃溃疡及难愈合性伤口等多种临床应用方面具有巨大潜力。