clq meaning in English
补体第一成分q亚单位
Examples
- On binding to specific carbohydrate structures on the surface of a broad range of microorganisms , mbl can activate complement system through the activation of mbl - associated serine proteases ( masps ) in antibody - and clq - independent way
甘露聚糖结合凝集素( mannan - bindinglectin ， mbl )是c型凝集素超级家族中胶凝素家族成员。 - Usually , clr is binding to c1inh ( cl inhibitor ) . when immune complex ( ic ) binds to clq , c1inh is detached form clr , and then the serine protease is activated , and then the complement classical pathway is activated
在一般情况下， c1r与c1inh ( c1inhibitor )结合着，而一旦有免疫复合物( ic )结合到c1q上时，浙江大学硕士学位论文cllnh的抑制作用即行移除， clr的构象发生改变，具有酶活性，从而启动补体激活经典途径。 - In this study , a novel strategy to inhibit the activation of the complement system has been developed . to get the purified clq as the target molecule for biopanning , the first step of our purification was to isolate the clq from clr2cls2 by affinity chromatography on igg - sepharose 4b column
本研究另辟蹊径，以补体经典激活途径始动分子c1q为靶标，采用噬菌体肽库技术，亲和筛选能与c1q结合的噬菌体克隆，研制可抑制补体激活的c1q模拟短肽。 - By elisa analysis , inhibition of binding of clq with the c ! q receptors on u937 cells and competitive inhibition of binding of clq with aggregated immunoglobulin g b y selected phage clones , and dna sequencing , a number of similar , but not identical , sets of sequences of clq - binding clones were identified . the deduced amino acid sequences of selected 9 peptides are wyegpftlytwp , hwdpfslsayfp , ltqhnspffllp , tsnpfflwypqp , qtpfqlw , npfnwts , spfxlts , fltwldp and fstflyp . they show significant efficiency to inhibit the binding of clq with the clq receptors on u937 cells and / or aggregated immunoglobulin g , which suggest that the selected peptides contain the modeling epitopes of clq receptor to bind the collage - like region or igg to bind the head domain of clq
然后，采用噬菌体肽库技术，以c1q为钓饵蛋白，从12肽库和环7肽库中亲和筛选能与c1q结合的噬菌体克隆，经elisa 、 u937细胞配体结合抑制试验、 aigg竞争抑制试验及dna测序，获得了9个具c1q抑制活性克隆的dna序列，其相应的氨基酸序列为： wyegpftlytwp 、 hwdpfslsayfp 、 ltqhnspffllp 、 tsnpfflwypqp 、 qtpfqlw 、 npfnwts 、 spfxlts 、 fltwldp 、 fstflyp ，它们可能模拟c1qr和或igg的c1q结合表位并抑制c1q的活性。