azalanstat meaning in English

阿扎兰司他

Inhibitors of cyp51 , such as azalanstat ( rs - 2i607 ) and rs - 2i745 , could inhibit the synthesis of ff - mas to decrease the accumulation of ff - mas . inhibitor of a14 - reductase , such as ay9944 - a - 7 , could inhibit the metabolism of ff - mas to increase the accumulation of ff - mas ; and some other reagents , such as nystatin , could combine with the downstream intermediate in the cholesterol biosynthesis pathway to accumulate mas . in this study , we investigated the role of mas by using these reagents to change the level of endogenous ff - mas
抑制cyp51酶的抑制剂，如azalanstat ( rs - 21607 )和rs - 21745等，均能抑制mas的合成，降低mas的积累；而抑制14 -还原酶的抑制剂，如ay9944 - a - 7等，能抑制ff - mas向t - mas的转化而造成ff - mas的积累；还有一些物质，如制霉菌素，能阻止mas向下游的代谢而造成其积累，本文主要通过应用这些物质降低、或增加组织细胞中内源性mas的积累，来研究mas的作用。